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162,163 The pharmacological basis of their action is increasingly being elucidated through both in vitro and in vivo experimental models, especially in conditions like IBS, peptic ulcers, GERD, and IBD, such as Crohns disease and ulcerative colitis
Chronic ethanol feeding Male mice (1012 wk old) were fed a modified Lieber-DeCarli (LD) diet (F4473SP and F4474SP
Clin Nutr 40(3):661689
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What is Kojic Acid
Studies finding protective effects against cancer: A meta-analysis found that two copies of the C677T variant (AA genotype) decrease the risk of colon cancer by about 20%![ref] Another meta-analysis found that two copies of the C677T variant (AA genotype) were protective against prostate cancer .[ref] The MTHFR C677T variant decreases the relative risk of retinoblastoma and oral squamous cell cancer.[ref][ref] Two copies of the C677T variant (AA genotype) are protective against gastric cancer.[ref] However, for someone who has cancer, the MTHFR C677T variant is associated with poorer outcomes.[ref] The MTHFR A1298C variant (GG or GT) is associated with a decreased risk of hypothyroidism .[ref] The flip side: Folate can also help protect against cancerous mutations in the first place
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