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How GLP-1s Work: Appetite, Dopamine, and Reward GLP-1 receptor agonists act primarily in the gut , but their effects reach far beyond digestion

In studies so far, the most commonly reported side effects have involved the digestive system

4 GABAA receptors reduce dendritic spine density in CA1 hippocampus and impair relearning ability of adolescent female mice: effects of a GABA agonist and a stress steroid

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Finally, TRANSCEND-T2D-3 (NCT06297603) will compare retatrutide to placebo over 14 months, in people with inadequately controlled T2D and moderate-or-severe renal impairment on basal insulin