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Complement component C3 production and activation of complement and coagulation cascades, as highlighted by single-gene Gene Set Enrichment Analysis of immune-related biomarkers (CXCL12, PDGFRL, AGTR1, PTGER3, S1PR1), further support the involvement of inflammatory pathways in disease pathogenesis (69)

Shortening (part of the Maillard reaction) increases neuronal nitric oxide synthase (nNOS) activity, which can lead to excessive signaling, reactive nitrogen species, and cell toxicity (97)

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H., Li, H., Peng, X