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BMC Psychiatry 25, 609

Stress & Anxiety Relief: Achieve greater emotional balance

Tinnitus: Animal models and findings in humans

For pigment specifically, a randomized, vehicle-controlled trial found topical tretinoin significantly improved melasma (a randomized vehicle-controlled trial showing topical tretinoin improves melasma), and a separate vehicle-controlled study confirmed the benefit specifically in patients with darker skin (a vehicle-controlled trial of topical tretinoin for melasma in darker skin)

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An overview of participant recruitment, screening, and attrition is provided in Fig