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Effects of degenerated intervertebral discs on intersegmental rotations, intradiscal pressures, and facet joint forces of the whole lumbar spine

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These sites are cleaved by the AP endonuclease, APE1, and corresponding nucleotides are then located into the gap by a DNA polymerase through two different sub-pathways, to finally be ligated by a DNA ligase (Krokan and Bjoras, 2013)

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Studies have found that berberine can effectively alleviate the motor dysfunction of HTT mice and prolong their survival time, further studies proves that berberine promote the degradation of mutant HTT protein through enhancing autophagy function, thereby reducing the accumulation of mutant huntingtin protein (Jiang et al., 2015b)

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