Intracellular glutathione also followed the trend of GCLC, exhibiting an NFT-dependent increase that was reversed by anti Nrf2-siRNA to levels comparable to those observed in untreated HepG2 cells (Fig
These alterations manifest behaviorally as earlier wake times and bedtimes, the classic advanced sleep phase tendency of the elderly, and fragmented, less robust daily patterns of activity, body temperature, and hormone levels
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After treatment with salidroside, Nrf2, and HO-1 were significantly restored, cardiac apoptosis, hypertrophy, and fibrosis were also improved [109]
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