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OxPhos is achieved in the presence of saturating ADP levels and the sequential addition of different mitochondrial substrates, including pyruvate, malate, glutamate (N-linked, through complex I) and succinate (S-linked, through complex II)

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Researchers should consult the primary literature and follow institutional protocols, including appropriate handling given copper's toxicity profile at higher concentrations

In addition, a non-enzymatic product of the prostaglandin D2 synthase gene ( PGD2S ), whose expression is upregulated by acetylcarnitine treatment with 100 mg/kg body weight [134], has been shown to have anti-inflammatory properties that may help protect the brain from ischemiareperfusion injury [72]

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