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Puerarin-loaded PLGA were orally administered to Sprague-Dawley rats, where pharmacokinetic analysis showed a 10.52-fold increase in plasma bioavailability and a 6.46-fold increase in brain puerarin accumulation compared to oral administration of free puerarin

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For broader clinical use, however, these benefits require systematic and well-designed clinical validation ( Peucedanum ostruthium shows anti-tubercular potential in silico, with nine bioactive compounds mapped to 256 TB-related genes

Zinc : used in addition to penicillamine, as zinc prevents copper absorption and increases its excretion 13 Trientine : an alternative for patients who cannot tolerate penicillamine Surgical management Patients presenting with acute liver failure or decompensated cirrhosis may require a liver transplant

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Xu D, Wu L, Yao H et al (2022) Catalase-like nanozymes: Classification, catalytic mechanisms, and their applications