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Description

Bimagrumab prevents muscle loss associated with low dietary protein intake in healthy volunteers or with weight loss in obesity

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25(OH)VD, 1,25(OH) 2 VD, VDBP, GSH, TNF-, PTH, insulin, glucose, protein carbonyl, and MDA assays Plasma levels of 25(OH) vitamin D were determined using an ELISA kit (Calbiotech, Spring Valley, CA) and 1,25(OH) 2 vitamin D using another ELISA kit (My BioSource, San Diego, CA)

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The cytokines TNF, IL-6, and chemokines activate cellular pathways such as the MAPK, and JAK/STAT pathways and activate TGF- receptors that promote inflammation and stimulate fibroblast/pericyte activation

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