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Abstract The majority of anticancer agents have a reduced or even complete loss of a therapeutic effect within hypoxic tumors

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4 Discussion The clinical importance of DDI cannot be overemphasized

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Mayo Clinic Proceedings.

The activated Akt signaling pathway activates downstream mTOR via the Akt-mTOR axis to promote protein synthesis, while also inhibiting NF-B and the binding of myostatin promoter, reducing myostatin expression to mitigate muscle atrophy (136-138)