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Whereas low rhGH-doses did not result in significant changes in GFR or glomerular sclerosis index compared to controls, medium and high-dose rhGH-treatment resulted in a significantly lower creatinine clearance and glomerularsclerosis index
[DOI] [PubMed] [Google Scholar] [62].Madsen K, Knudsen LB, Agersoe H, Nielsen PF, Thogersen H, Wilken M, Johansen NL, Structure-activity and protraction relationship of long-acting glucagon-like peptide-1 derivatives: importance of fatty acid length, polarity, and bulkiness, Journal of medicinal chemistry, 50 (2007) 61266132
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12,13,14,15,16 Therefore, either allergic (i.e., Th2 high or extrinsic) or nonallergic (i.e., Th2 low or intrinsic) asthma can be treated by targeting these cell signaling mediators
