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The subunit is encoded by the IDH3A gene which is located on chromosome 15q25.1 and is composed of 12 exons that encode a precursor protein of 366 amino acids

Renal function: NSAIDs can impair kidney function, particularly in patients with pre-existing renal impairment, dehydration, or those taking other nephrotoxic medications

Though rare, high blood pressure has been reported in some patients

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By activating these receptors in the brains satiety centers (like the area postrema), it promotes feelings of fullness, reduces food intake, and helps stabilize post-meal blood sugar spikes, making it a promising candidate for weight management, particularly in combination with the GLP-1 receptor agonist semaglutide (marketed as CagriSema)