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Orlistat es un inhibidor no sistmico de las lipasas gastrointestinales, las cuales son necesarias para desdoblar la grasa del tracto gastrointestinal, ejerce su accin a nivel del lumen del estmago e intestino delgado

doi: 10.1016/j.cmet.2011.03.009

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Pharmacologic approaches to glycaemic treatment: Standards of medical care in diabetes

Documented effects include increased appetite (expected from ghrelin-receptor activation), mild fluid retention and lower-extremity edema, muscle pain, weight gain, raised fasting glucose, and decreased insulin sensitivity