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J Burn Care Res 35(2):e83-92 Carter DW, Sood RF, Seaton ME, Muffley LA, Honari S, Hocking AM et al (2018) MC1R gene polymorphisms are associated with dysfunctional immune responses and wound infection after burn injury

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The immune system cant make the difference between the bodys own cells and a pathogen, so it responds by creating an inflammatory process

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The assessment was performed using the major adverse cardiac event (MACE)4 composite that includes cardiovascular death, myocardial infarction, stroke, and unstable angina hospitalization