Gut-derived LPS engages TLR4 along the hepatobiliary axis to promote cholangiocarcinoma (CCA)
It also showed that lymphatic-specific inhibition of mitochondrial complex III (a component of the electron transport chain that plays an important role in cellular metabolism) suppresses metastasis and enhances the response to immunotherapy in preclinical models
Theanine is not used for protein synthesis, but has many health benefits related to its free radical-scavenging, anti-inflammatory, immune-modulating, and calming effects
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Fitzpatricks dermatology in general medicine
By contrast, MAMP/translocation axes act as punctate, contextual danger cues whose benefits are maximized when (i) structural agonism is favorable (for example, hexa-acylated LPS), (ii) exposure can be localized (tumor or draining nodes), and (iii) the engaged PRR skews toward antitumor immunity (for example, NOD2 over NOD1 in CRC)