Glutathione supplementation can also be considered in resistant or recurrent melasma as part of adjunctive therapy
The body can convert GSSG back into the active GSH form using an enzyme called glutathione reductase, provided there are adequate levels of NADPH, a compound integral to many cellular processes, including the antioxidant response
(14 February 2003)
Carter BZ, PhD, Mak PY, Tao W, Ostermann LB, BS, Boettcher S, Nishida Y, MD, PhD, Ayoub E, PhD, Ruvolo V, MS, Jabbour EJ, MD, Hughes P, Morrow PK, Andreeff M , MD, PhD
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53.4 Mechanisms of methaemoglobinaemia and haemolysis