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It can actually travel to the hippocampus, and at least in these animal studies, induce the proliferation of neurons, growth of synapses, BDNF, a number of downstream things, which kind of makes sense if we were to put a just-so evolutionary story on this

Front Psychiatry 10 , 97 (2019)

Mller cell-localized G-protein-coupled receptor 81 (Hydroxycarboxylic Acid Receptor 1) regulates inner retinal vasculature via Norrin/Wnt pathways

REM cycles lengthen through the night, with the longest REM periods occurring in the final hours of sleep

Moreover, it is consistent with accumulating evidence that individuals exposed to chronic stress show signs of accelerated biological aging, such as systemic inflammation and shorter telomere length

235 For example, an experimental study of non-small cell lung cancer demonstrated that STF sensitized cancer cells to anti-PD-1 therapy