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Given that inhibition of IGF-IR may paradoxically lead to upregulation of IGF1/2 expression, and IGF1/2 have IGF-IR/InsR-independent functions, it warrants to investigate whether co-targeting IGF and IGF-IR/InsR-A may achieve objective responses

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Di Stefano, G., Maarbjerg, S., Nurmikko, T., Truini, A

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If you see anything suspect, do not use it