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Randomized clinical trial data have shown that both medications lead to significant weight loss

Intensified GI side effects Alcohol irritates the stomach lining and alters gut motility independently of tirzepatide

Important safety information includes a boxed warning for thyroid C-cell tumors (contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2), and warnings for pancreatitis, gallbladder disease, acute kidney injury risk, diabetic retinopathy complications, and suicidal behavior/ideation (for the weight management indication)

Extra virgin olive oil (1-2 tablespoons for cooking or dressing)

Insert the needle into the vial and push the air in

Importantly, no safety signals emerged suggesting problematic interactions between the medications