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When injected, the vaccine teaches the immune system to bind to the drug molecule and remove it from circulation
Melatonin has antioxidant properties and prevents toxic effects of reactive oxygen species by maintaining cellular glutathione homeostasis
Moreover, when they inhibited the expression, they observed a reduction in the production of type II collagen and aggrecan, main components of nucleus pulposus tissue
Therefore, ACh signaling in non-neuronal cells is another process potentially affected by TD before the deficiency develops into the well-known dry or wet beriberi
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*Correspondence: Arjola Bano, [email protected] These authors have contributed equally to this work This article was submitted to Cardiovascular and Smooth Muscle Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
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