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With these points in mind, we undertook a broad assessment of published clinical data, curating the body weight loss (% from baseline), glycosylated hemoglobin levels (HbA1c), and nausea responses (% patients reporting) from the SUSTAIN 3, SUSTAIN 7, SCALE Diabetes, SURPASS 2, and STEP 2 trials (17, 22, 64, 66, 67) ( Figures 1AC )
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Doses are adjusted by healthcare providers depending on medical condition, body weight, and treatment objectives
Whether this pro-tumorigenic effect also accounts for CRC is still unclear, while potential underlying molecular mechanisms still must be elucidated
That same mechanism explains why stomach-related symptoms are among the most common complaints, particularly after starting treatment or increasing the dose
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