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Comment: Several commenters expressed broad support for unpackaging payments

Epidemiological studies have shown that long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs), statins, histamine H2 receptor blockers, or vascular calcium channel blockers appears to prevent AD (Vagnucci and Li 2003)

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Higher-dose oral B12 (e.g., 1000 g daily) is sometimes used but should only be considered under clinical supervision with appropriate monitoring, particularly in cases of malabsorption where intramuscular treatment remains the first-line approach in UK practice

Because many peptide suppliers operate in loosely regulated markets, product consistency is another major issue