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Mitochondrial dysfunction in age-related metabolic disorders

Recent studies with both humans and mice have revealed that cardiac injury leads to 5-oxoprolinase depletion, resulting in elevated 5-OP levels in the plasma (Van Der Pol et al., 2018, 2017)

Most of what we know comes from short-term use

Moreau N, Martens T, Fleury MB, Leroy JP (1990) Metabolism of oltipraz and glutathione reductase inhibition

However, the analysis of clinical trials of B-vitamin supplementation has shown that lowering homocysteine concentrations did not prevent the occurrence of a second cardiovascular event in patients with existing CVD (88-90)

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