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Many harmful and potentially carcinogenic substances are present in mainstream smoke

Cipollone had been a smoker since the age of 16, and she would die of lung cancer less than a year into her suit

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The cause was reportedly cardiac arrest, with no foul play suspected

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[6] A 2015 study hypothesized from the data that at high voltage (5.0 V), a user, "vaping at a rate of 3 mL/day, would inhale 14.4 3.3 mg of formaldehyde per day in formaldehyde-releasing agents." [17] The 2015 study used a puffing machine showed that a third-generation e-cigarette turned on to the maximum setting would create levels of formaldehyde between five and 15 times greater than with cigarette smoke