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The glutamate N -methyl-D-aspartate receptor (NMDAR) antagonist ketamine was recently repurposed as a rapidly acting antidepressant, catalysing the vigorous investigation of glutamate-signalling modulators as novel therapeutic agents for depressive disorders

J., Santos, H

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This may be because their inhibitory activity is disrupted in vivo or they are unable to counteract chronic mucosal inflammation in UC

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