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Covariate adjustment had non-uniform effects on the magnitude of associations, with some reports showing no effect of covariate adjustment and other studies showing a reduction in the estimate from unadjusted to adjusted models

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The use of tobacco is responsible for many chronic and severe conditions such as lung cancer, heart and respiratory diseases

Additionally, the cigarettes must be sold on the reserve or delivered directly to the customer on the reserve

Moreover, government regulations can lead cigarette brands to increase production costs and reduce the number of pack-size options available to consumers