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The numbers speak clearly

Interactions between cationic peptides and negatively charged oligonucleotides can enhance toxicity, affect pharmacokinetic and pharmacological properties, and limit the efficacy of these therapies

95% CI: 0.36, 7.30

J Clin Pharmacol 60(3):409421 Arp J, Rieder MJ, Urquhart B, Freeman D, Tucker MJ, Krizova A, Lehmann D, Dekaban GA (2005) Hypersensitivity of HIV-1-infected cells to reactive sulfonamide metabolites correlated to expression of the HIV-1 viral protein tat

The changes in gene transcription led to changes in the synthesis of proteins that affect various physiological processes, including metabolism, development, and growth