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Eli Lilly has indicated an NDA filing in Q4 2026 at the earliest, which realistically puts an FDA decision in 2027 or later

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Additional preclinical work published in Cell Chemical Biology evaluated NNMT inhibition in similar diet-induced obesity models and confirmed the pattern: significant reductions in body weight gain, adipose tissue expansion, and circulating triglycerides compared to untreated controls

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The collagen group showed significant WOMAC pain score improvement: -1.90 4.14 versus +0.61 3.97 for placebo (p=0.006)