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Cell 140:883899 Lee J, Taneja V, Vassallo R (2012) Cigarette smoking and inflammation: cellular and molecular mechanisms

Extracellular mtDNA acts as a potent damage-associated molecular pattern, activating Toll-like receptor 9 (TLR9) and driving NF-Bdependent induction of transforming growth factor-, a central mediator of fibrogenesis (Bueno et al., 2019)

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If you are smoking a pack a day, you could be spending upwards of 450 every month