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As with all investigational medicines, the safety profiles of cagrilintide and retatrutide are still being characterised through ongoing clinical trials

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This high dosage is specifically supported by long-term clinical trials demonstrating its efficacy in raising cellular stores over time

Food and Drug Administration also says in its safety profiles of these drugs that they should not be taken during pregnancy, noting there is "insufficient data" available

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Mares-Perlman JA, Fisher AI, Klein R, Palta N, Block G, Millen AE, et al