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Isoform 1 and isoform 2 are ly involved in signal transduction due to their association with the TYR kinase, JAK1

28 HernndezI.ChacnO.RodriguezR.PortielesR.LpezY.PujolM.et al (2009)

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Within this context, it is not surprising that a great deal of inhibitors and pro-drugs targeting GSTs have been synthesized and tested so far, with new scaffolds or analogues being reported every year

Their mechanism involves enhancing mitophagy, suppressing NLRP3 inflammasome activation in hepatocytes, and modulating key metabolic regulators