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Diffusion Through Lipid Non-polar drug molecules passively diffuse across the membrane lipid according to its permeability coefficient, P, and the concentration difference across the membrane

When the dry powders are hydrated with water or body fluids followed by gentle mixing, (as in the stomach), the contents rapidly disperse to give a liposomal suspension in the aqueous solution

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In addition, patients with PWS have a higher incidence of metabolic complications, such as CVD, T2D, hypertension, and obstructive sleep apnea [5, 14, 15], thus contributing to increased morbidity and mortality in these patients [14, 16]

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