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Research suggests it may stimulate the release of growth hormone from the pituitary gland without affecting cortisol levels

For patients first prescribed an AOM in June 2025, 46.8% filled a GLP-1 RA within 60 days

However, factors such as aging, poor diet, stress, and environmental toxins can deplete glutathione levels, leading to oxidative stress and accelerated aging

The mechanism involves bacterial fermentation of dietary fiber into short-chain fatty acids, particularly butyrate and propionate

Another study suggested that oxidative stress-induced 4-hydroxy-2-nonenal (HNE) triggers mitochondrial translocation of AIFM2, promoting apoptosis in cardiac tissues of both mice and humans 40

Note that these two documented starting doses are worlds apart in size 150 mcg versus 2.5 mg is a roughly 17-fold difference