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this cascade further increases HK2, PFKFB3, and LDHA expression, establishing a self-reinforcing loop that drives high glycolytic flux [95]
Both dialysis modalities are also associated with disruption of the intestinal barrier integrity, which facilitates the translocation of endotoxins and contributes to systemic inflammation [165]
Environmental Triggers The immune system becomes dysregulated when people are exposed to toxins as well as heavy metals and industrial pollutants throughout extended periods
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