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This rescue operation potentially allows the immune system to reset, stopping the continuous, inappropriate inflammatory signaling that drives daily symptoms and supporting a more balanced, effective immune response

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This last, coupled with hyperhomocysteinemia, promotes the infiltration of leukocytes into the skin, which release additional inflammatory cytokines that stimulate MMP-9 expression and activity, leading to the formation of painful nodules, and hypodermal tracts [102] (Fig

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