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Only puff number and duration was measured to assess patterns of use

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Based on thirds of the range of scores, four studies were considered high quality with NOS scores of 8 or 9 17, 22, 25, 37 , ten studies were considered medium quality with NOS scores of 6 or 7 18, 21, 23, 26, 38,39,40, 42, 44, 45 , and eight studies were considered low quality with NOS scores of 4 to 5.5 19, 20, 24, 27, 28, 32, 41, 43 (Supplementary Tables S1 and S2)

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Carvedilol (CAR) combined with carnosic acid (CAA) attenuates doxorubicin-induced cardiotoxicity by suppressing excessive oxidative stress, inflammation, apoptosis and autophagy