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Quick Answer: Semaglutide is working if you experience reduced appetite, improved blood glucose levels (for diabetes), and gradual weight loss, typically noticeable within 24 weeks, with full effects developing over 36 months

In total, 5,468 patients (56.7%) had established CV disease without CKD, 1,241 (13%) had CKD only, and 2,620 (27%) had both CV disease and CKD

It is a formulation issue