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For T1DM patients, insulin replacement is essential due to insufficient endogenous insulin secretion

Healthcare providers can prescribe medications for a purpose outside the approved indications on the drugs labeling

Multiple randomised, placebo-controlled trials have tested GLP-1 drugs as add-on therapy to insulin in people with T1D, and the picture that emerges is consistent, if modest: meaningful weight loss, real reductions in daily insulin needs, and improvements in CGM time in range

These symptoms are generally mild and tend to subside after a few days or weeks

Semaglutide binds to and activates GLP-1 receptors in various tissues, including the pancreas, brain, and gastrointestinal tract

Their sublingual semaglutide starts at $249 per month