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[] Gastrointestinal symptoms, including nausea, vomiting, and diarrhea, are the most commonly reported adverse effects

NICE guideline NG28 recommends GLP-1 agonists for type 2 diabetes when metformin and other oral agents prove insufficient, particularly in people with a BMI 30 kg/m (or 27

In a matched pair casecontrol study done by Kobori et al

For example, the STEP 1 trial of once-weekly semaglutide (2.4 mg) in people without diabetes achieved a ~15% average body weight reduction over 68 weeks (source), with a mean baseline BMI of ~38 (source)

if the relationship is confirmed as causal, it could be exploited in future therapies [621]

Together, these approaches help users stay consistent with calorie targets without feeling overly restricted