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Standard titration protocol The standard titration schedule progresses through five dose levels, with each dose maintained for four weeks before escalation: Weeks 1-4: 0.25 mg once weekly (initiation dose) Weeks 5-8: 0.5 mg once weekly Weeks 9-12: 1.0 mg once weekly Weeks 13-16: 1.7 mg once weekly Week 17 onward: 2.4 mg once weekly (maintenance dose) This 16-week titration period is not optional or merely suggested