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229,230 Conclusion In summary, GLP-1RAs and dual-receptor agonists targeting both GLP-1 and GIP receptors have introduced significant advancements in the management of endocrine and metabolic disorders and their associated complications, establishing themselves as central therapeutic modalities within this domain

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A large number of studies show that intestinal dysbiosis, bacterial overgrowth and increased intestinal permeability (intestinal leakage) contribute to the development of HT [25, 40, 83]