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Its systemic effects are what make it so compelling for researchers

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Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans

Chronic inflammation can be behind everything from joint pain to fatigue

In clinical trials, Ipamorelin was well tolerated, with no significant effects on prolactin or cortisol secretion compared to other GHRPs. van den Berghe et al., The Journal of Clinical Endocrinology & Metabolism Rare or Potential Concerns Injection site irritation (especially with poor reconstitution technique) Overstimulation of GH axis with excessive dosing or stacking GH-related side effects at high doses (e.g., mild carpal tunnel, joint tightness) These are more likely in unsupervised high-dose or long-term protocols , especially when paired with additional GH-enhancing compounds

This raises questions about its safety with regards to cancer growth, especially in tissues known to form polyps or where there could be pre-existing tumor conditions 1