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The pattern across the timeline is that tolerability improves as effect accrues the roughest GI window is early, precisely when weight change is smallest, and by the time therapeutic doses are driving measurable change the gut has usually adapted to each step

Formula: Concentration = Vial mg / Water mL

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Nat Rev Endocrinol 3 , 302310 (2007)

Clinicians typically start patients at the middle ODT dose (5 mg) when switching from low-dose injectables (0.25 to 0.5 mg weekly) and titrate based on response

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