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In one study, it was demonstrated that exendin-4 prevented LPS-induced depressive-like symptoms in rats and displayed antidepressant-like properties measured in the forced swim test, but this effect was not mediated by the modulation of neuroinflammatory processes, since the levels of IL-1 and TNF- were not affected by exendin-4 treatment [67]

Because high blood pressure is one of the most common comorbidities associated with weight, the safety profile of tirzepatide regarding the cardiovascular system has been a major focus of clinical study

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Additionally, alterations in lipid distribution could cause concerns about where lipids would be stored and how it would be metabolized (114)

In line with the discussion above about DPP-IV inhibition by the methanolic and aqueous extract of U