In addition to the STEP trials, real-world studies and independent reviews further support the effectiveness of a variety of GLP-1 receptor agonists for weight management, with weight loss typically ranging from 5% to 15% depending on dose, duration, and adherence.28,29 A retrospective, noninterventional drug utilization cohort study in the United Kingdom evaluated the use of different varieties of liraglutide for weight management purposes.30 Among 604 individuals using Saxenda (liraglutide 3 g) and 4,853 individuals using Victoza (liraglutide 1.2 mg/1.8 mg), most were able to achieve 5% weight loss within 24 weeks.30 Emerging data on tirzepatide has also shown even greater weight reductions (up to 21% over 72 weeks) over other GLP-1s, as well as improved quality of life.31,32 Together, these findings show the support GLP-1s can provide in long-term weight management
E.KangK
It is commonly used in anti-aging peptide formulations to improve overall skin texture and tone
R.ZarrinparA
This result can be improved by using an aggressive laser along with a biostimulatory filler (like hyperdilute sculptra or radiesse), which will restore and repair the collagen in this area, as well as erase sun damage and deep wrinkles
In some cases, there is also a degree of muscle loss, which can give the legs a deflated or wasted appearance rather than a toned one
