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Conclusions and perspective Iron is integral to numerous essential biological processes, and disturbances in iron homeostasis can result in various pathological conditions

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The arcuate nucleus (ARC) at the floor of the third ventricle has received particular attention because it lies either side of the median eminence (ME) which, like the AP, is not fully shielded by the bloodbrain barrier [121] and has fenestrated capillaries therefore permitting access to circulating factors that control energy balance [122]

10.3390/cells11010014 27 Di DonatoM.ZamagniA.GalassoG.Di ZazzoE.GiovannelliP.BaroneM