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Also, especially in the context of inflammation and infectious conditions, cysteine can be depleted, because it is utilized for some other purposes in the body, like the production of acute-phase reactants

Recent studies found that transcription factors such as p53, the tumor suppressor BAP1 (BRCA1-associated protein 1), and ATF3 (activating transcription factor 3) increase cellular susceptibility to ferroptosis via decreased cystine uptake by inhibiting SLC7A11 expression [50,51,52]

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doi:10.4061/2010/876940