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Daily subcutaneous dosing at 0.160.25mg is mandatory due to the 33-minute plasma half-life

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This analysis further assessed whether the increase in DRP was a GLP-1 specific effect, or rather caused by a robust and early glucose lowering as suggested by several other studies, where acute and large reductions in glucose concentrations may initially and transiently worsen DRP, yet prevent or delay onset or progression of DRP in the long term (123128)

They should be swallowed whole with a small amount of plain water after fasting for at least 8 hours