continued reperfusion based on ischemia for 60 min
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While Mounjaro was initially approved for diabetes, the active ingredient (Tirzepatide) is widely prescribed off-label for weight management in patients without diabetes
Beyond pancreatic effects, GIP receptor agonism enhances peripheral insulin sensitivity, particularly in adipose tissue, where it promotes healthy white adipose tissue (WAT) expansion, facilitates dietary triglyceride clearance through increased lipoprotein lipase activity and adipose blood flow, and improves lipid buffering capacity [40]
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Thyroid concerns Animal studies identified thyroid C-cell tumours with GLP-1 receptor agonists