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The Swedish Medical Products Agency (Lkemedelsverket) and EMA require a prescription because these medicines: Require individual dose titration, incorrect dosing can produce severe adverse effects including nausea, ileus, and pancreatitis

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This condition can manifest as infrequent bowel movements or difficulty passing stools, which may result in significant discomfort

Ray JG, OBrien TE, Chan WS

Episodes of CVS are abrupt and distinct, in that there is a clear onset of each episode, and not a gradual progression